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Article

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

Blood - 1 Feb 2008

Kim Hyung-Gyoon, Kojima Kyoko, Swindle C Scott, Cotta Claudiu V, Huo Yongliang, Reddy Vishnu, Klug Christopher A

Abstract excerpt

The inversion of chromosome 16 in the inv(16)(p13q22) is one of the most frequent cytogenetic abnormalities observed in acute myeloid leukemia (AML). The inv(16) fuses the core binding factor (CBF) beta subunit with the coiled-coil rod domain of smooth muscle myosin heavy chain (SMMHC). Expression of CBFbeta-SMMHC in mice does not promote AML in the absence of secondary mutations. Patient samples with the inv(16)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 17967943
DOI: 10.1182/blood-2006-06-030312
PMCID: PMC2214774

Genes

FLT3
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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