Article
FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.
Blood - 1 Feb 2008
Kim Hyung-Gyoon, Kojima Kyoko, Swindle C Scott, Cotta Claudiu V, Huo Yongliang, Reddy Vishnu, Klug Christopher A
Abstract excerpt
The inversion of chromosome 16 in the inv(16)(p13q22) is one of the most frequent cytogenetic abnormalities observed in acute myeloid leukemia (AML). The inv(16) fuses the core binding factor (CBF) beta subunit with the coiled-coil rod domain of smooth muscle myosin heavy chain (SMMHC). Expression of CBFbeta-SMMHC in mice does not promote AML in the absence of secondary mutations. Patient samples with the inv(16)...
Topics
- Animals
- Chromosome Inversion
- Core Binding Factor beta Subunit
- Disease Progression
- Hematopoietic Stem Cells
- Leukemia, Myeloid, Acute
- Lymphopoiesis
- Mice
- Mutation
- Myelopoiesis
- Oncogene Proteins, Fusion