Article

Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemia

2019-08-12

Abstract excerpt

<h4>ABSTRACT</h4> The hematopoietic system is maintained throughout life by hematopoietic stem cells that are capable of differentiating into all hematopoietic lineages. An intimate balance between self-renewal, differentiation, and quiescence is required to maintain hematopoiesis. Disruption of this balance can result in hematopoietic malignancy, including acute myeloid leukemia (AML). FBXO9, from the F-box E3 u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd40d9d1-4009-57f0-88c4-b794d657a2b4
DOI: 10.1101/732198

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemiaDOI 10.1101/732198Read

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of mitochondrial LONP1Semantic proximity Read

FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndromeSemantic proximity Read

Tissue Specific Requirement for the Inv(16) Oncogene <i>CBFB::MYH11</i> in Acute Myeloid LeukemiaSemantic proximity Read

Functional Interrogation of <i>HOXA9</i> Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screenSemantic proximity Read

RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia developmentSemantic proximity Read

The role of ASXL1, SRSF2, and EZH2 mutations in chromatin dysregulation of myelodysplastic neoplasia and acute myeloid leukemia.Semantic proximity Read

<i>PBX3</i> is essential for leukemia stem cell maintenance in <i>MLL</i>‐rearranged leukemiaSemantic proximity Read

FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemiaSemantic proximity Read

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.Semantic proximity Read

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.Semantic proximity Read

RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9Semantic proximity Read

<i>Hox</i> gene Dysregulation in Acute Myeloid LeukemiaSemantic proximity Read