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Article

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination.

Nature communications - 30 Sept 2021

Ambjørn Sara M, Duxin Julien P, Hertz Emil P T, Nasa Isha, Duro Joana, Kruse Thomas, Lopez-Mendez Blanca, Rymarczyk Beata, Cressey Lauren E, van Overeem Hansen Thomas, Kettenbach Arminja N, Oestergaard Vibe H, Lisby Michael, Nilsson Jakob

Abstract excerpt

Mutations in the tumour suppressor gene BRCA2 are associated with predisposition to breast and ovarian cancers. BRCA2 has a central role in maintaining genome integrity by facilitating the repair of toxic DNA double-strand breaks (DSBs) by homologous recombination (HR). BRCA2 acts by controlling RAD51 nucleoprotein filament formation on resected single-stranded DNA, but how BRCA2 activity is regulated during HR...

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Share to BRCA2 Protein
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34593815
DOI: 10.1038/s41467-021-26079-0
PMCID: PMC8484605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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