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Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair

8 Oct 2018

Abstract excerpt

Resistance to genotoxic therapies is a primary cause of treatment failure and tumor recurrence. The underlying mechanisms that activate the DNA damage response (DDR) and allow cancer cells to escape the lethal effects of genotoxic therapies remain unclear. Here, we uncover an unexpected mechanism through which pyruvate kinase M2 (PKM2), the highly expressed PK isoform in cancer cells and a master regulator of...

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PMID: 30297868
DOI: 10.1038/s41422-018-0086-7

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