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Article

Pan-cancer analysis of co-occurring mutations in RAD52 and the BRCA1-BRCA2-PALB2 axis in human cancers.

PloS one - 1 Jan 2022

Hamid Abdulaziz B, Frank Lauren E, Bouley Renee A, Petreaca Ruben C

Abstract excerpt

In human cells homologous recombination (HR) is critical for repair of DNA double strand breaks (DSBs) and rescue of stalled or collapsed replication forks. HR is facilitated by RAD51 which is loaded onto DNA by either BRCA2-BRCA1-PALB2 or RAD52. In human culture cells, double-knockdowns of RAD52 and genes in the BRCA1-BRCA2-PALB2 axis are lethal. Mutations in BRCA2, BRCA1 or PALB2 significantly impairs error...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fanconi Anemia Complementation Group N Protein

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Share to Rad52 DNA Repair and Recombination Protein

Source

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Identifiers

PMID: 36107942
DOI: 10.1371/journal.pone.0273736
PMCID: PMC9477347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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