Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation

Abstract excerpt

Notch hyperactivation dominates T-cell acute lymphoblastic leukemia development, but the mechanisms underlying “pre-leukemic” cell dissemination are still unclear. Here we describe how deregulated Notch3 signaling enhances CXCR4 cell-surface expression and migratory ability of CD4 + CD8 + thymocytes, possibly contributing to “pre-leukemic” cell propagation, early in disease progression. In transgenic mice...

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