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Article

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.

The Journal of clinical investigation - 2 Jul 2018

García-Peydró Marina, Fuentes Patricia, Mosquera Marta, García-León María J, Alcain Juan, Rodríguez Antonio, García de Miguel Purificación, Menéndez Pablo, Weijer Kees, Spits Hergen, Scadden David T, Cuesta-Mateos Carlos, Muñoz-Calleja Cecilia, Sánchez-Madrid Francisco, Toribio María L

Abstract excerpt

NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL), but crucial NOTCH1 downstream signals and target genes contributing to T-ALL pathogenesis cannot be retrospectively analyzed in patients and thus remain ill defined. This information is clinically relevant, as initiating lesions that lead to cell transformation and leukemia-initiating cell (LIC) activity are promising...

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Source

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Identifiers

PMID: 29781813
DOI: 10.1172/JCI92981
PMCID: PMC6025994

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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