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Unveiling the therapeutic potential of Ponatinib and Imatinib against Aurora Kinase A in gastric cancer cells

2023-07-27

Abstract excerpt

<title>Abstract</title> <p>Aurora kinase A (AURKA) is considered a promising therapeutic target because of its abnormal expression pattern in multiple cancers. Since AURKA possesses a high similarity in active binding site with other kinases, we attempted to investigate and rationalize several kinase inhibitors that are currently under preclinical and clinical settings. All such inhibitors were selected based on...

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Literature Corpus work
e4d93534-4f63-57b4-92b6-4590a69fafbb
DOI
10.21203/rs.3.rs-3195156/v1
Open publication

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Unveiling the therapeutic potential of Ponatinib and Imatinib against Aurora Kinase A in gastric cancer cellsDOI 10.21203/rs.3.rs-3195156/v1
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