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Identification of polypharmacological anticancerous molecules against Aurora kinase family of proteins

17 Jan 2022

Abstract excerpt

The Human Aurora Kinase (AURK) protein family is the key player of cell cycle events including spindle assembly, kinetochore formation, chromosomal segregation, centrosome separation, microtubule dynamics, and cytokinesis. Their aberrant expression has been extensively linked with chromosomal instability in addition to derangement of multiple tumor suppressors and oncoprotein regulated pathways. Therefore, the...

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PMID: 35040172
DOI: 10.1002/jcb.30214

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