Article

Depletion of CCR8+ Treg cells restores CCR7+ dendritic cell function to drive anti-tumor immunity

2026-05-19

Abstract excerpt

<title>Abstract</title> <p> CCR8-targeted regulatory T (Treg) cell depletion is a potent strategy to overcome tumor immunosuppression, yet the cellular mechanisms driving the subsequent immune response have remained unclear. This study demonstrates that anti-CCR8 antibody treatment promotes anti-tumor immunity by specifically relieving CCR7 <sup>+</sup> dendritic cells (DCs) from Treg cell-mediated suppression...

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Literature Corpus work: e4c89031-bb62-5dc2-acee-7ea185a733c3
DOI: 10.21203/rs.3.rs-9597953/v1

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