Article

Anti-SLC7A11 monoclonal antibody Inhibits Tumor Progression through a Janus-faced Effect on CD4 + and CD8 + T Cells in Colorectal Cancer

2026-05-08

Abstract excerpt

<title>Abstract</title> <p>Background SLC7A11 is aberrantly overexpressed in many solid tumors, including colorectal cancer (CRC), but its complex 12-transmembrane structure has hindered effective antibody targeting. Methods We generated a human SLC7A11-specific murine monoclonal antibody (SLC7A11-Ab) using cell-based immunization and hybridoma technology. Subcutaneous and orthotopic CRC mouse models were estab...

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Literature Corpus work: cea1e0b6-b122-5985-9bab-8df977349385
DOI: 10.21203/rs.3.rs-8946667/v1

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