Article

Loss of ACKR4 in tumor cells dysregulates dendritic cell migration to tumor-draining lymph nodes and T-cell priming

2021-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal cancer (CRC) is one of the most common malignancies in both morbidity and mortality. Immune checkpoint blockade (ICB) treatments have been successful in a portion of mismatch repair-deficient (dMMR) CRC patients but failed in the mismatch repair-proficient (pMMR) CRC patients. Atypical Chemokine Receptor 4 (ACKR4) is known for regulating dendritic cell (DC) migration. However, the rol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5856b43-e940-5dd9-8a69-8f8e1cb724de
DOI: 10.1101/2021.08.23.457444

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of ACKR4 in tumor cells dysregulates dendritic cell migration to tumor-draining lymph nodes and T-cell primingDOI 10.1101/2021.08.23.457444Read

Depletion of CCR8+ Treg cells restores CCR7+ dendritic cell function to drive anti-tumor immunitySemantic proximity Read

Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancerSemantic proximity Read

Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancerSemantic proximity Read

Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside.Semantic proximity Read

Centrosomal Protein 55 (CEP55) Drives Immune Exclusion and Resistance to Immune Checkpoint Inhibitors in Colorectal CancerSemantic proximity Read

Antitumor immunity in dMMR colorectal cancers requires interferon-induced CCL5 and CXCL10Semantic proximity Read

Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasisSemantic proximity Read

COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancerSemantic proximity Read

Targeting the Atypical Chemokine Receptor 2 (ACKR2) improves the benefit of anti-PD-1 immunotherapy in melanomaSemantic proximity Read

CXCL14 suppresses the progression of colon cancer by regulating tumor epithelial-mesenchymal transition and tumor microenvironmentSemantic proximity Read

Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer.Semantic proximity Read

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancerSemantic proximity Read