Article

CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype

2024-03-21

Abstract excerpt

<title>Abstract</title> <p>Regulatory T cells (Tregs) are main immunosuppressive cells in tumor immune microenvironment (TIME). However, systemic Treg depletion is not favored due to the crucial role of Tregs in the maintenance of immune homeostasis and prevention of autoimmunity. Recently, CCR8 has been identified as a key chemokine receptor expressed on tumor-infiltrating Tregs and targeted blockade exerts anti...

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Literature Corpus work: cc3bb023-bd93-520e-a448-9a6a841156ec
DOI: 10.21203/rs.3.rs-4121011/v1

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