Article

Rewiring dendritic cell function with CLEC9A and DEC205-based chimeric antigen receptors

2026-02-18

Abstract excerpt

<title>Abstract</title> <p>Dendritic cells (DCs) are central orchestrators of anti-tumor immunity, yet their therapeutic utility has been limited by dysfunction and insufficient activation within solid tumors. Here, we report chimeric antigen receptor-engineered DCs (CAR-DCs) that potently prime T cells and reprogram the tumor microenvironment. We identify the intracellular domains of CLEC9A or DEC205 as essentia...

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Literature Corpus work: ca7509c4-266e-531c-b306-2940c6622270
DOI: 10.21203/rs.3.rs-8658068/v1

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