Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease?

Brain research - 13 Jan 2014

Koutseff Alexis, Mittelhaeuser Christophe, Essabri Karim, Auwerx Johan, Meziane Hamid

Abstract excerpt

Apolipoprotein E (ApoE) is found in three different forms in humans (ApoE2, ApoE3 and ApoE4), and ApoE polymorphism is recognized as a major risk factor for Alzheimer's disease (AD). ApoE is involved in lipid and cholesterol transport, cell repair, and amyloid-β deposition and certain studies suggest potential implications in neurogenesis. In this regard, we investigated the possible impact of the three different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bromodeoxyuridine

Share to Flow Cytometry

Share to Hippocampus

Share to Neurogenesis

Share to Neurons

Share to Sex Characteristics

Source

Identifiers

PMID: 24140109
DOI: 10.1016/j.brainres.2013.10.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease?PMID 24140109Read ↗

Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats.Semantic proximity Read ↗

In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis.Semantic proximity Read ↗

ApoE is required for maintenance of the dentate gyrus neural progenitor pool.Semantic proximity Read ↗

Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic miceSemantic proximity Read ↗

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.Semantic proximity Read ↗

APOE2, E3 and E4 differentially modulate cellular homeostasis, cholesterol metabolism and inflammatory response in isogenic iPSC-derived astrocytesSemantic proximity Read ↗

<i>APOE</i> deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoidsSemantic proximity Read ↗

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.Semantic proximity Read ↗

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.Semantic proximity Read ↗

17α-Estradiol Confers Limited Protection Against <i>APOE4</i> Phenotypes in Middle-Aged Female MiceSemantic proximity Read ↗

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s DiseaseSemantic proximity Read ↗

Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.