Article

A receptor-independent signaling pathway for BDNF

2022-08-23

Abstract excerpt

In addition to its well-known receptor-mediated function in cell survival, differentiation and growth, we report that the extracellular brain-derived neurotrophic factor (BDNF) also controls the intracellular KEAP1-NRF2 cytoprotective system by a receptor-independent pathway. Extracellular BDNF can cross the cell membrane as it possesses a protein-translocation domain, also known as cell-penetrating peptide. This...

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Literature Corpus work: e4c013a2-a891-5d67-bc88-cadd932ab01e
DOI: 10.1101/2022.08.23.504973

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