Article

Preclinical and Toxicology Assessment of ISFP10, an Inhibitor of Fungal Phosphoglucomutase (PGM)

2025-01-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Objective</h4> Previously, the novel small molecule ISFP10 has been shown to inhibit fungal phosphoglucomutase (PGM) activity in Aspergillus fumigatus and Pneumocystis spp. With 50-fold selectivity over the human PGM molecule due to the presence of a unique yet conserved cysteine residue present in a number pathogenic fungal PGMs, use of this compound may provide a novel br...

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Literature Corpus work: e4be22cd-957b-5182-a86c-c919a3c3dc70
DOI: 10.1101/2025.01.07.631740

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