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The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti- <i>Aspergillus</i> activity <i>in vitro</i> and in a treatment model of fungal keratitis

2024-08-08

Abstract excerpt

<h4>Objective</h4> The fungal unfolded protein response consists of a two-component relay in which the ER-bound sensor, IreA, splices and activates the mRNA of the transcription factor, HacA. Previously, we demonstrated that hacA is essential for Aspergillus fumigatus virulence in a murine model of fungal keratitis (FK), suggesting the pathway could serve as a therapeutic target. Here we investigate the antifun...

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Literature Corpus work
4fce56a7-ab2d-5f63-8ebb-d1af6a1d9ac7
DOI
10.1101/2024.08.08.607189
Open publication

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The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti- <i>Aspergillus</i> activity <i>in vitro</i> and in a treatment model of fungal keratitisDOI 10.1101/2024.08.08.607189
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