Article
Characterisation of the Candida albicans Phosphopantetheinyl Transferase Ppt2 as a Potential Antifungal Drug Target.
PloS one - 1 Jan 2015
Dobb Katharine S, Kaye Sarah J, Beckmann Nicola, Thain John L, Stateva Lubomira, Birch Mike, Oliver Jason D
Abstract excerpt
Antifungal drugs acting via new mechanisms of action are urgently needed to combat the increasing numbers of severe fungal infections caused by pathogens such as Candida albicans. The phosphopantetheinyl transferase of Aspergillus fumigatus, encoded by the essential gene pptB, has previously been identified as a potential antifungal target. This study investigated the function of its orthologue in C. albicans,...
Topics
- Amino Acid Sequence
- Antifungal Agents
- Bacterial Proteins
- Candida albicans
- Carrier Proteins
- Computational Biology
- Enzyme Activation
- Gene Expression
- Molecular Sequence Data
- Phenotype
- Promoter Regions, Genetic
- Sequence Alignment
- Sequence Deletion