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What do we know about the role of gliotoxin in the pathobiology of<i>Aspergillus fumigatus?</i>

12 May 2008

Abstract excerpt

Gliotoxin is a member of the epipolythiodioxopiperazine class of toxins and is both the major and the most potent toxin produced by Aspergillus fumigatus. Since the discovery of the putative gliotoxin biosynthetic 12-gene cluster in the genome of A. fumigatus, five different laboratories have attempted to determine the role of this toxin in the virulence of A. fumigatus. The genes in the cluster that have been...

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PMID: 18608908
DOI: 10.1080/13693780802056012

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Related research

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Research trail→

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What do we know about the role of gliotoxin in the pathobiology of<i>Aspergillus fumigatus?</i>PMID 18608908Read ↗

GliZ, a Transcriptional Regulator of Gliotoxin Biosynthesis, Contributes to<i>Aspergillus fumigatus</i>VirulenceSemantic proximity Read ↗

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<i>Aspergillus fumigatus</i>: Principles of Pathogenesis and Host DefenseSemantic proximity Read ↗

Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeriSemantic proximity Read ↗

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The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulenceSemantic proximity Read ↗

Characterizing the pathogenic, genomic, and chemical traits of <i>Aspergillus fischeri</i> , a close relative of the major human fungal pathogen <i>Aspergillus fumigatus</i>Semantic proximity Read ↗

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