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Plasma Gelsolin Prevents Organ-Specific Inflammation and Enhances Innate Immune Function in a Systemic <i>Candida albicans</i> Infection

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Systemic Candida albicans infections (candidemia) remain a significant cause of morbidity and mortality in immunocompromised patients, mainly due to severe inflammation, organ damage, and delayed fungal clearance. Plasma gelsolin (pGSN), an actin-binding protein with immunomodulatory properties, has demonstrated protective effects in bacterial sepsis models, but its role in fungal infections re...

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Literature Corpus work
67b21a8e-97c4-52f4-ad12-63b9447cfb19
DOI
10.1101/2025.09.22.677758
Open publication

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Plasma Gelsolin Prevents Organ-Specific Inflammation and Enhances Innate Immune Function in a Systemic <i>Candida albicans</i> InfectionDOI 10.1101/2025.09.22.677758
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