Article

The aminoalkylindole, BML-190, negatively regulates chitosan synthesis via the cAMP/PKA1 pathway in <i>Cryptococcus neoformans</i>

2019-08-29

Abstract excerpt

Cryptococcus neoformans can cause fatal meningoencephalitis in patients with AIDS or other immune-compromising conditions. Current antifungals are suboptimal to treat this disease, therefore, novel targets and new therapies are needed. Previously, we have shown that chitosan is a critical component of the cryptococcal cell wall, is required for survival in the mammalian host, and that chitosan deficiency results i...

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Literature Corpus work: f50ca529-ec3a-5a53-9dc0-89064651ce1c
DOI: 10.1101/751172

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