Article

The pre-mRNA Splicing Modulator Pladienolide B Inhibits <i>Cryptococcus neoformans</i> Germination and Growth

2025-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Cryptococcus neoformans is an opportunistic fungal pathogen responsible for life-threatening infections, particularly in immunocompromised individuals. The limitations of current antifungal therapies due to toxicity and the emergence of resistance highlight the need for novel treatment strategies and targets. C. neoformans has an intron-rich genome, and pre-mRNA splicing is required for express...

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Literature Corpus work: 641127ef-702e-51e6-a8ab-17c893cbd5d4
DOI: 10.1101/2025.03.06.641977

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