Article
KRAB-ZFP Repressors Enforce Quiescence of Oncogenic Human Herpesviruses
26 Apr 2018
Abstract excerpt
ABSTRACT Cancer-causing herpesviruses infect nearly every human and persist indefinitely in B lymphocytes in a quiescent state known as latency. A hallmark of this quiescence or latency is the presence of extrachromosomal viral genomes with highly restricted expression of viral genes. Silencing of viral genes ensures both immune evasion by the virus and limited pathology to the host, yet how multiple genes on...
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