Article

GuidePro: A multi-source ensemble predictor for prioritizing sgRNAs in CRISPR/Cas9 protein knockouts

2020-07-12

Abstract excerpt

The efficiency of CRISPR/Cas9-mediated protein knockout is determined by three factors: sequence-specific sgRNA activity, frameshift probability, and the characteristics of targeted amino acids. A number of computational methods have been developed for predicting sgRNA efficiency from different perspectives. We propose GuidePro, a two-layer ensemble predictor that enables the integration of multiple predictive met...

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Literature Corpus work: e4a7ec21-7962-5c5c-b0a9-c9340a080943
DOI: 10.1101/2020.07.10.197996

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