Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2

Abstract excerpt

BACKGROUND: Casein kinase 2 (CK2) is involved in various cellular events such as proliferation, apoptosis, and the cell cycle. CK2 overexpression is associated with multiple human cancers and may therefore be a promising target for cancer therapy. To identity novel classes of inhibitors for CK2, we screened a natural product library obtained from National Cancer Institute. METHODS: The quantitative luminescent...

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