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Article

Protein kinase CK2: a potential therapeutic target for diverse human diseases.

Signal transduction and targeted therapy - 17 May 2021

Borgo Christian, D'Amore Claudio, Sarno Stefania, Salvi Mauro, Ruzzene Maria

Abstract excerpt

CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other well-known functions of CK2 are in human infections; in particular, several viruses exploit host cell CK2 for their life cycle....

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Identifiers

PMID: 33994545
DOI: 10.1038/s41392-021-00567-7
PMCID: PMC8126563

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