Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic targeting of CK2 in acute and chronic leukemias

27 Sept 2017

Abstract excerpt

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy explains the involvement of CK2 in many cellular events. However, its predominant roles are stimulation of cell growth and prevention of apoptosis. High levels of CK2 messenger RNA and protein are associated with CK2 pathological functions in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Chronic Lymphocytic Leukemia Research
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28951560
DOI: 10.1038/leu.2017.301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic targeting of CK2 in acute and chronic leukemiasPMID 28951560Read ↗

Biological functions and therapeutic potential of CKS2 in human cancerSemantic proximity Read ↗

CK2 and the Hallmarks of CancerSemantic proximity Read ↗

Protein kinase CK2: a potential therapeutic target for diverse human diseases.Semantic proximity Read ↗

The Role of Protein Kinase CK2 in Development and Disease Progression: A Critical ReviewSemantic proximity Read ↗

Targeting CK2 in cancer: a valuable strategy or a waste of time?Semantic proximity Read ↗

Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer CellsSemantic proximity Read ↗

Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma ManagementSemantic proximity Read ↗

Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cellsSemantic proximity Read ↗

CKS2 in human cancers: Clinical roles and current perspectives (Review)Semantic proximity Read ↗

Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid LeukemiaSemantic proximity Read ↗

CIGB-300-Regulated Proteome Reveals Common and Tailored Response Patterns of AML Cells to CK2 InhibitionSemantic proximity Read ↗

Protein kinase CK2 as a druggable targetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.