Back to search

Article

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

2023-02-15

Abstract excerpt

DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been implicated in age-related diseases, its functional role in aging remains unknown. Here, using mouse liver and cerebellum as model organs, we show that 5hmC accumulates in gene bodie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e493d32f-3525-54c9-b182-5a335b18176d
DOI
10.1101/2023.02.15.528714
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during agingDOI 10.1101/2023.02.15.528714
Early life DNA methylation profiles are indicative of age-related transcriptome changesSemantic proximity
Global remodeling of the mouse DNA methylome during aging and in response to calorie restrictionSemantic proximity
Single-cell Characterization of DNA Hydroxymethylation of the Mouse Brain During AgingSemantic proximity
Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation.Semantic proximity
Tissue-specific 5-hydroxymethylcytosine landscape of the human genomeSemantic proximity
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome.Semantic proximity
Distinct chromatin signatures of DNA hypomethylation in aging and cancerSemantic proximity
Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female miceSemantic proximity
Progress on the role of DNA methylation in aging and longevitySemantic proximity
The Aging Epigenome.Semantic proximity
DNA methylation and histone variants in aging and cancer.Semantic proximity
How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life SpanSemantic proximity
Select a neighboring publication to make it the new centre.