Article

Myosin binding protein-C limits strain induced cross-bridge detachment in response to rapid stretch in cardiac and skeletal muscle

2026-03-04

Abstract excerpt

Myosin binding protein-C (MyBP-C) consists of a family of regulatory proteins expressed in sarcomeres of cardiac, fast and slow twitch skeletal muscles. The 3 MyBP-C paralogs expressed in each muscle type are encoded by separate genes but maintain a similar structure. Given the overall similarity in structure and localization of each of paralog, it is assumed that MyBP-C expressed in different muscles have similar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e487050b-cc0b-5d50-afc0-1981dea259e8
DOI: 10.64898/2026.03.02.709089

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myosin binding protein-C limits strain induced cross-bridge detachment in response to rapid stretch in cardiac and skeletal muscleDOI 10.64898/2026.03.02.709089Read

SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMSSemantic proximity Read

Cardiac myosin binding protein C: its role in physiology and disease.Semantic proximity Read

Myosin-binding protein C forms C-links and stabilizes OFF states of myosinSemantic proximity Read

Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systemsSemantic proximity Read

MYBPC1, an Emerging Myopathic Gene: What We Know and What We Need to LearnSemantic proximity Read

The E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Loaded Crossbridge CyclingSemantic proximity Read

Missense variants in the myosin binding domains of <i>MYBPC3</i> and <i>MYBPHL</i> impair sarcomere incorporationSemantic proximity Read

Signaling and myosin-binding protein C.Semantic proximity Read

Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs.Semantic proximity Read

cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities.Semantic proximity Read

The N-Terminal Mutations of cMyBP-C Affect Calcium Regulation, Kinetics, and Force of Muscle Contraction.Semantic proximity Read

Fast Myosin Binding Protein-C is a Vital Regulator in Young and Aged Fast Skeletal Muscle HomeostasisSemantic proximity Read