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Article

The N-Terminal Mutations of cMyBP-C Affect Calcium Regulation, Kinetics, and Force of Muscle Contraction.

International journal of molecular sciences - 13 Dec 2024

Nabiev Salavat R, Kopylova Galina V, Nefedova Victoria V, Matyushenko Alexander M, Shchepkin Daniil V, Bershitsky Sergey Y

Abstract excerpt

The cardiac myosin binding protein-C (cMyBP-C) regulates cross-bridge formation and controls the duration of systole and diastole at the whole heart level. As known, mutations in cMyBP-C increase the cross-bridge number and rate of their cycling, hypercontractility, and myocardial hypertrophy. We investigated the effects of the mutations D75N and P161S of cMyBP-C related to hypertrophic cardiomyopathy on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39769170
DOI: 10.3390/ijms252413405

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