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Article

Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems

7 Oct 2019

Abstract excerpt

Significance Myosin-binding protein C (MyBP-C) is a critical component of the skeletal muscle sarcomere, muscle’s smallest contractile unit. MyBP-C’s importance is evident by genetic mutations leading to human myopathies, such as distal arthrogryposis (i.e., club foot). However, the molecular basis of MyBP-C’s functional impact on skeletal muscle contractility is far from certain. Complicating matters further is...

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PMID: 31591218
DOI: 10.1073/pnas.1910549116

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