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Article

MYBPC1, an Emerging Myopathic Gene: What We Know and What We Need to Learn

13 Sept 2016

Abstract excerpt

Myosin Binding Protein-C (MyBP-C) comprises a family of accessory proteins that includes the cardiac, slow skeletal, and fast skeletal isoforms. The three isoforms share structural and sequence homology, and localize at the C-zone of the sarcomeric A-band where they interact with thick and thin filaments to regulate the cycling of actomyosin crossbridges. The cardiac isoform, encoded by MYBPC3, has been...

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Identifiers

PMID: 27683561
DOI: 10.3389/fphys.2016.00410

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