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Article

Effects of Aicardi-Goutières syndrome mutations predicted from ADAR-RNA structures.

RNA biology - 1 Feb 2017

Fisher Andrew J, Beal Peter A

Abstract excerpt

Adenosine (A) to inosine (I) RNA editing is important for life in metazoan organisms. Dysregulation or mutations that compromise the efficacy of A to I editing results in neurological disorders and a shorten life span. These reactions are catalyzed by adenosine deaminases acting on RNA (ADARs), which hydrolytically deaminate adenosines in regions of duplex RNA. Because inosine mimics guanosine in hydrogen...

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Source

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Identifiers

PMID: 27937139
DOI: 10.1080/15476286.2016.1267097
PMCID: PMC5324757

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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