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Article

Structural impacts of two disease-linked ADAR1 mutants: a molecular dynamics study.

Journal of computer-aided molecular design - 17 Jul 2024

Huang Wen-Chieh, Hsu Chia-Hung, Albu Titus V, Yang Chia-Ning

Abstract excerpt

Adenosine deaminases acting on RNA (ADARs) are pivotal RNA-editing enzymes responsible for converting adenosine to inosine within double-stranded RNA (dsRNA). Dysregulation of ADAR1 editing activity, often arising from genetic mutations, has been linked to elevated interferon levels and the onset of autoinflammatory diseases. However, understanding the molecular underpinnings of this dysregulation is impeded by...

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Identifiers

PMID: 39014124
DOI: 10.1007/s10822-024-00565-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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