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<i>APOE</i> ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

10 Sept 2014

Abstract excerpt

Brain pathology of Alzheimer's diseases (AD) and the genetics of autosomal dominant familial AD have been the "lamp posts" under which the AD field has been looking for therapeutic targets. Although this approach still remains valid, none of the compounds tested to date have produced clinically meaningful results. This calls for developing complementary therapeutic approaches and AD targets. The allele ε4 of...

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PMID: 25217293
DOI: 10.1016/j.jalz.2014.06.015

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