Article

Regulation of RAS-GTPase Activity by Oncofetal Chondroitin Sulfate (Chondroitin 4-Sulfate) and Arylsulfatase B

2026-08-19

Abstract excerpt

<title>Abstract</title> <p>RAS-GTPase is the most common and well-known genetic driver of human malignancies. Inhibition of RAS-GTPase activity has proven extremely challenging, and therapeutic strategies targeting RAS and RAS-driven pathways have had limited success. Recent advances targeting specific RAS mutations have shown benefit. Additional approaches based on the underlying mechanisms of RAS activation may...

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Literature Corpus work: e47c061a-9a4b-5f0d-823f-d8cc37d4c10f
DOI: 10.21203/rs.3.rs-10671758/v1

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