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Article

Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis.

Communications biology - 25 Jan 2021

Kitazawa Kazuyuki, Nadanaka Satomi, Kadomatsu Kenji, Kitagawa Hiroshi

Abstract excerpt

Chondroitin sulfates are implicated in epidermal biology, but functional significance of chondroitin sulfates remains unclear. Here, we report that chondroitin 6-sulfate is important for the maintenance of epidermal homeostasis. Mice deficient in chondroitin 6-O-sulfotransferase-1 (C6st-1), which is involved in biosynthesis of chondroitin 6-sulfate, exhibited keratinocyte hyperproliferation and impaired skin...

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Source

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Identifiers

PMID: 33495490
DOI: 10.1038/s42003-020-01618-5
PMCID: PMC7835381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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