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Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate

30 Aug 2024

Abstract excerpt

Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One such embryonic signature tumors express is oncofetal chondroitin sulfate (ofCS), which supports disease progression and dissemination in cancer. Here, we report the identification and characterization of phage display-derived antibody fragments recognizing...

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PMID: 39215044
DOI: 10.1038/s41467-024-51781-0

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