Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.

Nature cell biology - 1 Dec 1999

Eisenmann K M, McCarthy J B, Simpson M A, Keely P J, Guan J L, Tachibana K, Lim L, Manser E, Furcht L T, Iida J

Abstract excerpt

Melanoma chondroitin sulphate proteoglycan (MCSP) is a cell-surface antigen that has been implicated in the growth and invasion of melanoma tumours. Although this antigen is expressed early in melanoma progression, its biological function is unknown. MCSP can stimulate the integrin-alpha4 beta1-m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cdc42 GTP-Binding Protein
Share to Chondroitin Sulfate Proteoglycans
Share to Integrins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphotyrosine

Share to Precipitin Tests

Share to Protein-Tyrosine Kinases

Share to Receptors, Lymphocyte Homing

Share to Retinoblastoma-Like Protein p130

Source

Identifiers

PMID: 10587647
DOI: 10.1038/70302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10587647-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.PMID 10587647Read ↗

Melanoma Proteoglycan Modifies Gene Expression to Stimulate Tumor Cell Motility, Growth, and Epithelial-to-Mesenchymal TransitionSemantic proximity Read ↗

Exogenous Recombinant N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B; ARSB) Inhibits Progression of B16F10 Cutaneous Melanomas and Modulates Cell SignalingSemantic proximity Read ↗

Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF.Semantic proximity Read ↗

Integrin signaling in malignant melanoma.Semantic proximity Read ↗

Role of the CD47-SHPS-1 system in regulation of cell migration.Semantic proximity Read ↗

A chondroitin sulfate proteoglycan 4‑specific monoclonal antibody inhibits melanoma cell invasion in a spheroid model.Semantic proximity Read ↗

Regulation of RAS-GTPase Activity by Oncofetal Chondroitin Sulfate (Chondroitin 4-Sulfate) and Arylsulfatase BSemantic proximity Read ↗

Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin productionSemantic proximity Read ↗

Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK.Semantic proximity Read ↗

Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasionSemantic proximity Read ↗

Positive crosstalk between ERK and p38 in melanoma stimulates migration and in vivo proliferation.Semantic proximity Read ↗

Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.