Article
The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.
Molecular cell - 15 Mar 2018
Lin Ruiting, Xia Siyuan, Shan Changliang, Chen Dong, Liu Yijie, Gao Xue, Wang Mei, Kang Hee-Bum, Pan Yaozhu, Liu Shuangping, Chung Young Rock, Abdel-Wahab Omar, Merghoub Taha, Rossi Michael, Kudchadkar Ragini R, Lawson David H, Khuri Fadlo R, Lonial Sagar, Chen Jing
Abstract excerpt
Dietary supplements such as vitamins and minerals are widely used in the hope of improving health but may have unidentified risks and side effects. In particular, a pathogenic link between dietary supplements and specific oncogenes remains unknown. Here we report that chondroitin-4-sulfate (CHSA), a natural glycosaminoglycan approved as a dietary supplement used for osteoarthritis, selectively promotes the tumor...
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