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Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression.

Cells - 20 Dec 2021

Chu Yin-Hung, Liao Wen-Chieh, Ho Ying-Jui, Huang Chih-Hsien, Tseng To-Jung, Liu Chiung-Hui

Abstract excerpt

Chondroitin sulfate (CS) is a major component of the extracellular matrix found to be abnormally accumulated in several types of cancer tissues. Previous studies have indicated that CS synthases and modification enzymes are frequently elevated in human gliomas and are associated with poor prognosis. However, the underlying mechanisms of CS in cancer progression and approaches for interrupting its functions in...

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Identifiers

PMID: 34944101
DOI: 10.3390/cells10123594
PMCID: PMC8700349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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