Article

Confident Identification and Quantification of Mouse Brain Tissues Reveals Sirtuin 5-Dependent Regulation

2026-05-28

Abstract excerpt

Methylmalonylation is a non-enzymatic lysine post-translational modification derived from methylmalonyl-CoA, a reactive intermediate that accumulates during mitochondrial dysfunction and branched-chain amino acid catabolism. Although reported in models of methylmalonic acidemia, its broader distribution and functional relevance remain largely unexplored. Progress has been hindered by a key analytical challenge: me...

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Identifiers and source

Literature Corpus work: e477dd83-56ab-52ac-b464-a686ed8162e0
DOI: 10.64898/2026.05.26.726073

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