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Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF

8 Apr 2025

Abstract excerpt

Fusobacterium nucleatum (Fn), a commensal in the human oral cavity, is overrepresented in the colon microbiota of colorectal cancer (CRC) patients and is linked to tumor chemoresistance, metastasis, and a poor therapeutic prognosis. Fn produces numerous adhesins that mediate tumor colonization and downregulation of the host’s antitumor immune response. One of these, the trimeric autotransporter adhesin (TAA)...

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PMID: 40198705
DOI: 10.1073/pnas.2418155122

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