Back to search

Article

Characterization of a new anti-LAG3 monoclonal for immuno-oncology

2022-07-06

Abstract excerpt

<h4>Background: </h4> Lymphocyte activation gene 3 (LAG3) (CD223) is a T cell inhibitory receptor that promotes tumor cell immune escape, is associated with signaling pathways in multiple immune disorders and cancer, and is considered as a potential target for cancer diagnostic and immunotherapeutic applications. Targeting LAG3 towards these ends requires developing additional new antibodies. Here we compare the b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f6a6044b-6425-5667-b2ad-e4b24ad1063b
DOI
10.21203/rs.3.rs-1782118/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Characterization of a new anti-LAG3 monoclonal for immuno-oncologyDOI 10.21203/rs.3.rs-1782118/v1
High-Resolution Epitope Mapping and Affinity Binding Analysis Comparing a New Anti-Human LAG3 Rabbit Antibody Clone to the Commonly Used Mouse 17B4 CloneSemantic proximity
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3Semantic proximity
Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA)Semantic proximity
Development and characterization of Novel Small Molecule Inhibitors Targeting LAG-3 ProteinSemantic proximity
The Sentinel Within: Exploiting the Immune System for Cancer BiomarkersSemantic proximity
Seven mysteries of LAG-3: a multi-faceted immune receptor of increasing complexitySemantic proximity
Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.Semantic proximity
LAG-3: from molecular functions to clinical applicationsSemantic proximity
Design and Validation of the First-in-Class PROTACs for Targeted Degradation of the Immune Checkpoint LAG-3Semantic proximity
Development of a LAG-3 Immunohistochemistry Assay for MelanomaSemantic proximity
Gene of the month: lymphocyte-activation gene 3 (LAG-3)Semantic proximity
Antibodies for profiling the human proteome—The <scp>H</scp>uman <scp>P</scp>rotein <scp>A</scp>tlas as a resource for cancer researchSemantic proximity
Select a neighboring publication to make it the new centre.