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Article

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.

Communications biology - 19 Mar 2021

Gandhi Amit K, Sun Zhen-Yu J, Kim Walter M, Huang Yu-Hwa, Kondo Yasuyuki, Bonsor Daniel A, Sundberg Eric J, Wagner Gerhard, Kuchroo Vijay K, Petsko Gregory A, Blumberg Richard S

Abstract excerpt

Human (h) carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) function depends upon IgV-mediated homodimerization or heterodimerization with host ligands, including hCEACAM5, hTIM-3, PD-1, and a variety of microbial pathogens. However, there is little structural information available on how hCEACAM1 transitions between monomeric and dimeric states which in the latter case is critical for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33742094
DOI: 10.1038/s42003-021-01871-2
PMCID: PMC7979749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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