Article
The human disease network.
Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007
Goh Kwang-Il, Cusick Michael E, Valle David, Childs Barton, Vidal Marc, Barabási Albert-László
Abstract excerpt
A network of disorders and disease genes linked by known disorder-gene associations offers a platform to explore in a single graph-theoretic framework all known phenotype and disease gene associations, indicating the common genetic origin of many diseases. Genes associated with similar disorders show both higher likelihood of physical interactions between their products and higher expression profiling similarity...
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