Article

Genes with high network connectivity are enriched for disease heritability

2018-10-13

Abstract excerpt

Recent studies have highlighted the role of gene networks in disease biology. To formally assess this, we constructed a broad set of pathway, network, and pathway+network annotations and applied stratified LD score regression to 42 independent diseases and complex traits (average N =323K) to identify enriched annotations. First, we constructed annotations from 18,119 biological pathways, including 100kb windows a...

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Literature Corpus work: ae7dd9f6-e956-5141-aa4f-ccf042ffddda
DOI: 10.1101/442582

Open publication

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