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Article

Complete Characterization of the Seventeen Step Moenomycin Biosynthetic Pathway

29 Jul 2009

Abstract excerpt

The moenomycins are phosphoglycolipid antibiotics produced by Streptomyces ghanaensis and related organisms. The phosphoglycolipids are the only known active site inhibitors of the peptidoglycan glycosyltransferases, an important family of enzymes involved in the biosynthesis of the bacterial cell wall. Although these natural products have exceptionally potent antibiotic activity, pharmacokinetic limitations have...

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PMID: 19640006
DOI: 10.1021/bi901018q

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