Article
Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proceedings of the National Academy of Sciences of the United States of America - 10 May 2016
Siitonen Vilja, Selvaraj Brinda, Niiranen Laila, Lindqvist Ylva, Schneider Gunter, Metsä-Ketelä Mikko
Abstract excerpt
Nogalamycin, an aromatic polyketide displaying high cytotoxicity, has a unique structure, with one of the carbohydrate units covalently attached to the aglycone via an additional carbon-carbon bond. The underlying chemistry, which implies a particularly challenging reaction requiring activation of an aliphatic carbon atom, has remained enigmatic. Here, we show that the unusual C5''-C2 carbocyclization is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.